Vidéo montrant l'action de lymphocytes T sur des cellules cancereuses

sur cette vidéo réalisée en microcinématographie (photos prises a intervalles réguliers puis projetées ensuite à plusieurs images par seconde) avec un microscope á fluorescence, on voit des lymphocytes Tpatrouiller et détruire des cellules cancereuses.

voici les commentaires que l'on entend dans vidéo :

These are immune cells called cytotoxic T-cells.

Cytotoxic T-cells are able to recognize and kill virally infected and cancerous cells in the body.

These T-cells are on patrol...searching for their targets.

Let's take a closer look at how they move.

Cytotoxic T-cells are constantly migrating around your body.

They move through your tissues by pushing out the membrane at the leading edge of the cell and pulling themselves forward.

When a T-cell encounters a cancer cell...an explosion of membrane protrusions explore the surface of the target.

Cytotoxic T-cells kill their targets with toxic chemicals.

The chemicals are housed in these red structures called lattice granules. You can see the lattice granules polarize from the rear of theT-cell to the blue cancer cell.

These toxic granules secrete specifically toward the target...protecting innocent bystanders which may be nearby.

As the membrane of the target is compromised by the toxins in the granules...our indicator flashes bright red, signaling the impending death of the cancerous cell.

Movies like these allow us to study the efficiency with which cytotoxic T-cells operate.

Now we'll leave you with a few more movies of T-cells doing what they do best... killing cancer.

(Crédit : Etienne Doumazane)

 

 

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